Windows + Up Arrow
It is used to maximize the current window which is in focus, whether it is a windows explorer, a web browser, or any other application.
Windows + Left Arrow
Adjusts the current window to the left side and hence the window will cover almost half of the desktop space.
Windows + Right Arrow
It will adjust the current window to the right and thus it will cover half of the desktop space on the right.
Windows + Down Arrow
Minimizes the windows to the Task bar.
Windows + Space
All windows become transparent so you are able to see your desktop.
Windows + T
Shows the thumbnail preview of the running applications.
Windows + P
It is used to adjust the presentation options of the display on your computer or projector
Windows + (+ / -) (Add/Minus)
It launches the Magnifier which can be used to zoom in/zoom out.
Shift + Click a Taskbar item
It opens a new instance of the particular application on which you clicked.
Windows + F
Windows + F is used to start the Windows Search.
Windows + X
It is used to run the Windows Mobility Center.
Windows + E
It is used to open the Windows Explorer.
Windows + [number]
It is used to run the pinned applications on the taskbar, Windows + 1 will run the first pinned application on the task bar, similarly Windows + 2 will run the second pinned application and so on.
Windows + Tab
It will launch the Windows Aero task switcher. VERY COOL
Windows + Pause
It is used to load the system properties window.
Ctrl + Windows + F
Search for computers if you are on a network.
Ctrl + Shift + Click on icon [Task Bar]
It is used to open a new instance of the particular application from the taskbar with administrator privileges.
Alt + D
It is used to select the address bar.
Alt + Win + [number]
Opens the jump list for the applications which are pinned to the task bar.
Windows + B
It is used to shift the control to the System Tray icons one by one.
Shift + Right-click on a taskbar button
It is used to display the window menu for the specific taskbar application.
Ctrl + Shift + N
It is used to create a new folder in the windows explorer.
Alt + Up
Takes you up a folder level in the Windows Explorer.
Shift + Right-click on a file
It is used to add the Copy As Path option in the right click-menu of the file. This option copies the path of a file to the clipboard.
Shift + Right-click on a folder
It is used to add the command prompt option to the Folder, so you can easily open the command prompt in that particular folder.
Shift + Right-click on a grouped taskbar button
It is used to launch the windows menu for the group.
Ctrl + Click on a grouped taskbar button
It is used to cycle between the windows of the group.
Win + G
It is used to cycle between the Gadgets on the screen.
Ctrl + Esc
This hot key is used to open the Start Menu.
Ctrl + Shift+Esc
It is used to directly open the Windows Task Manager.